Cytotoxicity of monocrotaline in isolated rat hepatocytes: Effects of dithiothreitol and fructose
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منابع مشابه
Cytotoxicity of monocrotaline in isolated rat hepatocytes: effects of dithiothreitol and fructose.
Monocrotaline (MCT) is a pyrrolizidine alkaloid present in plants of the Crotalaria species that causes cytotoxicity and genotoxicity, including hepatotoxicity in animals and humans. It is metabolized by cytochrome P-450 in the liver to the alkylating agent dehydromonocrotaline (DHM). In previous studies using isolated rat liver mitochondria, we observed that DHM, but not MCT, inhibited the act...
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ژورنال
عنوان ژورنال: Toxicon
سال: 2011
ISSN: 0041-0101
DOI: 10.1016/j.toxicon.2011.04.010